I-DEW®MEGA contains 300mg of High Purity Omega-3 Fatty acids comprising of 180mg Eicosapentanoeic Acid (EPA) and 120mg Docosahexaenoic Acid (DHA).


Soft Gelatin Capsules (odourless and colourless)




Fish Oils obtained from a rich Sustainable Scandinavian source


The omega-3 group consists of essential FA Alpha-linolenic (ALA) and its derivatives, Eicsapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Essential fatty acids are necessary because they cannot be synthesized by the body and must be obtained from diet or supplement. They are found in flax seed oil and fish oil (Tuna). Deficiency of Omega-3 fatty acids has been demonstrated to have role in the development of dry eye. They suppress inflammation, stimulate aqueous tear production and help in the secretion of meibum. Vitamin E with omega3 fatty acid works synergistically to increase tear secretions.


Studies have shown that decreased dietary intake of Omega 3 fatty acid has a role in development of dry eye. Benefits of omega 3 fatty acid in dry eye management have been demonstrated in several studies. As per DEWS and Delphi guidelines, Omega 3 fatty acids are indicated in the treatment of dry eye from Level 2 onwards. EPA reduces apoptosis (Sjogrens Syndrome) and stimulates tear production. Emerging research has observed the effects of essential fatty acid (FA) on ocular inflammation and has lead to usage of dietary supplements for DES (Dry Eye Syndrome). Apart from this they also suppress inflammation (Blepharitis, Meibomitis), help in cornel regeneration after refractive surgery (Post LASIK dry eye), help in secretion of meibum [evaporative dry eye due to Meibomian gland dysfunction (MGD)] and reduce risk of dry eye.


An analysis of surveys from more than 30,000 women between 45 and 84 years of age led miljanovic et all to draw several statistically significant relationships between essential FA intake and prevalence of DES. Findings showed that women with diets high in omega -3FAs, especially DHA showed lower risk for development of DES.

Tuna fish consumption was inversely correlated with DES. In contrast participants whose diets had a high omega 6 to omega 3 ratio (15:1) were more than twice as likely to have DES. In a study patients with Blepharitis and MGD were prospectively evaluated to determine the effects of dietary supplementation with omega-3 fatty acids. Primary outcome measures were changes in tear breakup time (TBUT), Meibum score, and overall OSDI score.  At the end of 12 months time period omega -3 groups had an improvement in all three outcomes measures TBUT, OSDI score and Maibum score. When combined with DHA, vitamin E prevents apoptosis.


Increased TNF-a in the lacrimal gland increases lacrimal gland apoptosis ( programmed cell death). Increased apoptosis contributes to a decreasein tear production & increase in tearfilm osmolarity that drives dry eye ocular surface disorder.

EPA & DHA elongated with enzymes produces anti inflammatory prostaglandin E3 (PGE 3) & leukotrienes B5 (LTB 5)

EPA blocks the gene expression of pro inflammatory cytokines tumor necrosis factor alpha (TNF a), interleukin-1a (IL-1a), interleukin-1b (IL-1), proteoglycan degrading enzymes & cyclo oxygenase and thus reduces the inflammation.

Meibomian glands use essential fatty acids to synthesize oil. Omega 3 fatty acids clears & thins the meibomian gland secretions & stimulates tear secretions..


I-DEW®MEGA is indicated for chronic dry eyes, pre-operative and post-operative use.


The recommended dose of I-DEW®MEGA is one capsule a day in mild to moderate dry eyes. In more severe cases or in post-operative use, two capsules a day may be taken. In post-operative use a minimum of 30 days treatment may be required. Longer courses may be required for chronic dry eyes as recommended by the prescriber.


Omega 3 fatty acids should not be used in patients who are hypersensitive to any other ingredients.


Studies of EPA and DHA have not been conducted in pregnant women. It is recommended that pregnant and nursing women should obtain Omega – 3 fatty acids through dietary intake of fish (Tuna Fish) and other foods that are rich in omega-3 fatty acids. It is not known whether Omega 3 fatty acid supplementation of women during pregnancy or nursing is beneficial to infants. It has been suggested that high intake of Omega 3 fatty acids during pregnancy may increase birth weight and gestational length.


Oral supplementation with FAs has resulted in few adverse effects among study participants. The combination of EPA and DHA is generally recognized as safe.


Store in a cool dry place. Protect from light.


Disclaimer: The above product-related information is intended for use by medical professionals only.