Background Information

After years of advanced molecular research in Europe and the UK, and after analyzing several detailed population studies in India, Entod International’s research teams have designed and developed a novel form of Cholecalciferol called Ret-3D™ exclusively for the Indian market. The Cholecalciferol has been specially formulated in a unique oil blend with state-of-the-art soft-gelatin encapsulation. The highest pharmaceutical grade Cholecalciferol is used in the manufacture of this innovative product.

Population studies in India shows that 50% of the Indian population may be Vitamin D3 deficient despite ample sunlight throughout the year. The reasons for this may:

  • Insufficient Dietary Intake of Vitamin D3 in the Indian diet: Regular Consumption of High Fibre foods such as Chapattis contain phosphates and phytates which can deplete Vitamin D3 stores.
  • Heavy Pigmentation of Indian Skin which Interferes with UV ray transmission through the Epidermis.
  • Avoidance of Sun Exposure due to Increased Indoor Lifestyle and Growing Elderly/ House-bound populations.
  • Increased Pollution can hamper the ultraviolet rays to adequately synthesize Vitamin D3 in the skin.
  • Genetic Factors

Apart from Cholecalciferol’s traditional clinical indication of Vitamin D deficiency, Entod International has been the first pharmaceutical company in the world to associate its use in ophthalmology.

Several recent well-designed studies have shown that Cholecalciferol can result in:

  • Reduction in Retinal Inflammation
  • Reduction in levels of Amyloid Beta accumulation
  • Reduction in Retinal Macrophage numbers
  • Enhancement in Corneal Epithelial Barrier Function

Therefore there is now growing evidence of clinical benefits of cholecalciferol in relation to:

  • Improvement in Visual Function
  • Age-Related Macular Degeneration (AMD)
  • Diabetic Retinopathies
  • Smoking-Related Eye Diseases

For several years Cholecalciferol has been available from several pharmaceutical and nutraceutical companies worldwide. However its industrial scale production for use in vitamin supplements has been largely unchanged. Cholecalciferol is generally produced by the ultraviolet irradiation of 7-dehydrocholesterol extracted from  lanolin found in sheep’s wool. However this process leaves behind some unwanted isomers are formed during irradiation which can affect physical stability and alter potency.

Entod International however, have developed and designed an innovative technique to produce Vitamin D3 at its state-of-the-art plant in Europe which results in the production of the purest and most physically stable form of cholecalciferol. This novel form contains no isomers and therefore maintains its potency throughout the shelf-life of the product.


Scientific Evidence

Vitamin D3 Rejuvenates aging eyes by Reducing Inflammation, Clearing Amyloid Beta and Improving Visual Function – 2011
Vitamin D3 Status and Early Age-Related Macular Degeneration in Postmenopausal Women- 2011
Vitamin D3 supplements can fight against Age-Related Macular Degeneration- 2012
Association between Vitamin D3 and Age-Related Macular Degeneration – 2007
Vitamin D3 Deficiency: Indian Scenario – 2011
Vitamin D3 Enhances Corneal Epithelial Barrier Function- 2011
Taq I Polymorphism of the Vitamin D Receptor and Risk of Severe Diabetic Retinopathy – 2002
Association between a Protein Polymorphism in the Start Codon of the Vitamin D Receptor Gene and Severe Diabetic Retinopathy in C-Peptide-Negative Type 1 Diabetes- 2005

Click for Mechanism of Action of Ret-3D™


Indications and Dosage


  • Age-Related Macular Degeneration
  • Diabetic Retinopathies
  • Smoking-Related Eye Diseases
  • Vitamin D deficiency

Dosage :

  • The American Journal of Clinical Nutrition together with the Association of Physicians of India recommend a Safe Regular Supplementation of atleast 2000 IU/day (1 capsule of Ret-3D™ per day) of Vitamin D3  supplementation to Maintain Normal Vitamin D3  levels.


Disclaimer: The above information is intended for medical practitioners only